/* es-peptidos.es */
@font-face{font-family:"EP Titular";src:url(titular.woff2) format("woff2");font-weight:400 800;font-display:swap}
@font-face{font-family:"EP Texto";src:url(texto.woff2) format("woff2");font-weight:400 700;font-display:swap}
@font-face{font-family:"EP Texto";src:url(texto-it.woff2) format("woff2");font-weight:400;font-style:italic;font-display:swap}
:root{
--tinta:#2b1a33;--tinta-2:#5c4d63;--fondo:#fdfcfa;--lila:#f3eef5;--linea:#e4dbe8;--azafran:#e3a42b;--granate:#9b2f4f;--granate-o:#6f1d36;
--f-incretinas:#c27c12;--f-tejidos:#4f7a28;--f-eje-gh:#1d6b74;--f-mitocondria:#a3344c;--f-neuro:#5d4596;
--ancho:76rem;--radio:6px}
[data-f=incretinas]{--f:var(--f-incretinas)}[data-f=tejidos]{--f:var(--f-tejidos)}[data-f=eje-gh]{--f:var(--f-eje-gh)}[data-f=mitocondria]{--f:var(--f-mitocondria)}[data-f=neuro]{--f:var(--f-neuro)}
*,*::before,*::after{box-sizing:border-box}
html{-webkit-text-size-adjust:100%;scroll-behavior:smooth;scroll-padding-top:1.5rem}
body{margin:0;background:var(--fondo);color:var(--tinta);font:400 1.0625rem/1.72 "EP Texto",system-ui,-apple-system,"Segoe UI",sans-serif}
h1,h2,h3{font-family:"EP Titular",Georgia,serif;font-weight:600;line-height:1.12;letter-spacing:-.01em;text-wrap:balance;margin:0}
h1{font-size:clamp(2.1rem,4.6vw,3.6rem);font-weight:700}
h2{font-size:clamp(1.4rem,2.3vw,1.85rem);margin:2.6rem 0 .8rem}
h3{font-size:1.2rem}
p{margin:0 0 1rem}
a{color:var(--granate);text-decoration:underline;text-decoration-color:rgba(155,47,79,.35);text-underline-offset:.18em;text-decoration-thickness:1px}
a:hover{color:var(--granate-o);text-decoration-color:currentColor}
:focus-visible{outline:2px dashed var(--azafran);outline-offset:3px}
em{font-style:italic}
.ep-saltar{position:absolute;left:-999px;top:0;background:var(--azafran);color:var(--tinta);padding:.6rem 1rem;z-index:9}
.ep-saltar:focus{left:1rem}
/* cabecera */
.ep-cabecera{background:var(--tinta);color:#f6e7c8}
.ep-aviso{background:#1d1023;color:#e9c97f;font-size:.74rem;letter-spacing:.08em;text-transform:uppercase;text-align:center;padding:.45rem 1rem}
.ep-barra{max-width:var(--ancho);margin:0 auto;padding:1.1rem 1.5rem;display:flex;align-items:center;justify-content:space-between;gap:1.5rem;flex-wrap:wrap}
.ep-marca{display:flex;align-items:center;gap:.8rem;color:#fff;text-decoration:none}
.ep-marca:hover{color:#fff}
.ep-marca-sello{display:grid;place-items:center;width:2.7rem;height:2.7rem;border-radius:50%;border:3px dashed var(--azafran);font:italic 700 1.05rem/1 "EP Titular",serif;color:var(--azafran)}
.ep-marca-txt{font:600 1.55rem/1 "EP Titular",serif;letter-spacing:-.01em}
.ep-marca-txt em{color:var(--azafran);font-style:normal;padding:0 .05em}
.ep-marca-txt small{display:block;font:400 .72rem/1.4 "EP Texto",sans-serif;letter-spacing:.04em;color:#cdb9d4;margin-top:.3rem}
.ep-nav{list-style:none;margin:0;padding:0;display:flex;flex-wrap:wrap;gap:.25rem}
.ep-nav a{display:block;color:#f6e7c8;text-decoration:none;font-size:.95rem;padding:.45rem .8rem;border-radius:999px}
.ep-nav a:hover{background:rgba(255,255,255,.08);color:#fff}
.ep-nav a[aria-current]{background:var(--azafran);color:var(--tinta);font-weight:600}
/* estructura */
main{display:block}
.ep-hoja{max-width:var(--ancho);margin:0 auto;padding:1.5rem 1.5rem 4rem}
.ep-migas ol{list-style:none;margin:0 0 1.6rem;padding:0;display:flex;flex-wrap:wrap;font-size:.85rem;color:var(--tinta-2)}
.ep-migas li+li::before{content:"›";padding:0 .5rem;color:var(--azafran)}
.ep-migas a{color:var(--tinta-2)}
.ep-titulo{max-width:52rem;margin-bottom:2rem}
.ep-familia{font-size:.8rem;letter-spacing:.09em;text-transform:uppercase;font-weight:700;color:var(--f,var(--granate));margin-bottom:.7rem}
.ep-familia a{color:inherit;text-decoration:none}
.ep-entrada{font-size:1.2rem;line-height:1.6;color:var(--tinta-2);margin-top:1rem}
/* portada */
.ep-portada{max-width:var(--ancho);margin:0 auto;padding:3.5rem 1.5rem 2.5rem;display:grid;grid-template-columns:1.25fr 1fr;gap:3rem;align-items:center}
.ep-antetitulo{display:inline-block;border-bottom:2px solid var(--azafran);font-size:.82rem;letter-spacing:.07em;text-transform:uppercase;font-weight:600;color:var(--tinta-2);margin-bottom:1.2rem}
.ep-botones{margin-top:1.8rem;display:flex;flex-wrap:wrap;gap:.7rem}
.ep-boton{display:inline-block;background:var(--tinta);color:#fff;text-decoration:none;padding:.8rem 1.3rem;border-radius:var(--radio);font-weight:600}
.ep-boton:hover{background:var(--granate);color:#fff}
.ep-boton--claro{background:transparent;color:var(--tinta);box-shadow:inset 0 0 0 2px var(--tinta)}
.ep-boton--claro:hover{background:var(--lila);color:var(--tinta)}
.ep-rueda{width:100%;max-width:25rem;justify-self:center}
.ep-seg{fill:var(--f);opacity:.88;transition:opacity .15s}
.ep-rueda a:hover .ep-seg,.ep-rueda a:focus .ep-seg{opacity:1;stroke:var(--tinta);stroke-width:2}
.ep-rueda text{fill:#fff;font:700 11px "EP Texto",sans-serif;text-anchor:middle;pointer-events:none}
.ep-rueda-c{fill:var(--lila)}
.ep-rueda .ep-rueda-n{fill:var(--tinta);font:700 40px "EP Titular",serif}
.ep-rueda .ep-rueda-l{fill:var(--tinta-2);font:400 13px "EP Texto",sans-serif;letter-spacing:.08em}
/* catálogo */
.ep-catalogo{background:var(--lila);border-block:1px solid var(--linea)}
.ep-catalogo-cab,.ep-grupos{max-width:var(--ancho);margin:0 auto;padding:0 1.5rem}
.ep-catalogo-cab{padding-top:2.6rem;display:flex;justify-content:space-between;align-items:flex-end;gap:1rem;flex-wrap:wrap}
.ep-catalogo-cab h2{margin:0}
.ep-chips{display:flex;flex-wrap:wrap;gap:.4rem}
.ep-chip{font:600 .82rem "EP Texto",sans-serif;border:1.5px solid var(--f,var(--tinta));color:var(--f,var(--tinta));background:#fff;border-radius:999px;padding:.35rem .8rem;cursor:pointer}
.ep-chip[aria-pressed=true]{background:var(--f,var(--tinta));color:#fff}
.ep-grupos{padding-top:1.8rem;padding-bottom:3rem;columns:2 26rem;column-gap:2rem}
.ep-grupo{break-inside:avoid;background:#fff;border-radius:var(--radio);border-top:4px solid var(--f);padding:1.1rem 1.2rem .6rem;margin-bottom:1.6rem}
.ep-grupo[hidden]{display:none}
.ep-grupo h3{font-size:1.1rem;color:var(--f);margin-bottom:.5rem}
.ep-grupo ul{list-style:none;margin:0;padding:0}
.ep-grupo li+li{border-top:1px dotted var(--linea)}
.ep-grupo a{display:grid;grid-template-columns:2.2rem 1fr;column-gap:.6rem;padding:.6rem 0;text-decoration:none;color:var(--tinta)}
.ep-num{grid-row:span 2;font:600 .85rem/1.9 "EP Titular",serif;color:var(--f)}
.ep-nom{font-weight:700}
.ep-cls{font-size:.88rem;color:var(--tinta-2)}
.ep-grupo a:hover .ep-nom{color:var(--granate);text-decoration:underline}
.ep-dos{max-width:var(--ancho);margin:0 auto;padding:1rem 1.5rem 4rem;display:grid;grid-template-columns:1fr 1fr;gap:3rem}
.ep-flecha{font-weight:600;text-decoration:none}
.ep-flecha::after{content:" →"}
.ep-lista-num{counter-reset:n;list-style:none;padding:0;margin:0 0 1rem}
.ep-lista-num li{counter-increment:n;position:relative;padding-left:2.4rem;margin-bottom:.7rem}
.ep-lista-num li::before{content:counter(n);position:absolute;left:0;top:.1rem;width:1.7rem;height:1.7rem;border-radius:50%;background:var(--azafran);color:var(--tinta);font:700 .85rem/1.7rem "EP Titular",serif;text-align:center}
.ep-lista-check{list-style:none;padding:0}
.ep-lista-check li{position:relative;padding-left:1.8rem;margin-bottom:.6rem}
.ep-lista-check li::before{content:"";position:absolute;left:.15rem;top:.55em;width:.75rem;height:.4rem;border-left:2.5px solid var(--granate);border-bottom:2.5px solid var(--granate);transform:rotate(-45deg)}
/* ficha de compuesto */
.ep-rejilla{display:grid;grid-template-columns:minmax(0,1fr) 19rem;gap:3.5rem;align-items:start}
.ep-texto{max-width:46rem}
.ep-texto--ancho{max-width:50rem}
.ep-texto section>h2:first-child{margin-top:2.2rem}
.ep-indice-pag{border-left:3px solid var(--f,var(--azafran));padding:.2rem 0 .2rem 1.1rem;margin-bottom:1rem}
.ep-indice-pag p{font-size:.78rem;text-transform:uppercase;letter-spacing:.08em;font-weight:700;color:var(--tinta-2);margin:0 0 .3rem}
.ep-indice-pag ol{margin:0;padding-left:1.1rem;font-size:.95rem}
.ep-lateral{position:sticky;top:1.5rem}
.ep-ficha{background:var(--tinta);color:#f4ecf6;border-radius:var(--radio);padding:1.4rem 1.4rem 1rem;position:relative;overflow:hidden}
.ep-ficha::before{content:"";position:absolute;inset:0 0 auto;height:6px;background:var(--f)}
.ep-ficha-sig{font:700 3.6rem/1 "EP Titular",serif;color:var(--f);filter:brightness(1.35);margin:.2rem 0 .4rem}
.ep-ficha h2{font-size:1rem;letter-spacing:.1em;text-transform:uppercase;font-family:"EP Texto",sans-serif;margin:0 0 .8rem;color:#e9c97f}
.ep-ficha dl{margin:0}
.ep-ficha dt{font-size:.75rem;text-transform:uppercase;letter-spacing:.07em;color:#b9a6c1}
.ep-ficha dd{margin:0 0 .8rem;font-size:.95rem;overflow-wrap:anywhere}
.ep-nota{background:#fbf1dc;border-left:4px solid var(--azafran);border-radius:0 var(--radio) var(--radio) 0;padding:1rem 1.2rem;margin:2rem 0 .5rem;font-size:.95rem}
.ep-nota p{margin:0}
.ep-fuentes{border-top:1px solid var(--linea);margin-top:2.6rem}
.ep-fuentes h2{font-size:1.2rem}
.ep-fuentes ol{font-size:.9rem;color:var(--tinta-2);padding-left:1.2rem}
.ep-fuentes li{margin-bottom:.5rem}
.ep-afines{margin-top:3rem}
.ep-afines ul{list-style:none;margin:0;padding:0;display:grid;grid-template-columns:repeat(auto-fill,minmax(14rem,1fr));gap:1rem}
.ep-afines a{display:block;border:1px solid var(--linea);border-bottom:4px solid var(--f);border-radius:var(--radio);padding:1rem;text-decoration:none;color:var(--tinta);font-weight:700;background:#fff}
.ep-afines a span{display:block;font:700 1.6rem/1 "EP Titular",serif;color:var(--f);margin-bottom:.4rem}
.ep-afines small{display:block;font-weight:400;color:var(--tinta-2);font-size:.85rem}
.ep-afines a:hover{background:var(--lila)}
.ep-pasos{display:flex;justify-content:space-between;gap:1rem;margin-top:2.5rem;padding-top:1.5rem;border-top:1px solid var(--linea)}
.ep-pasos a{text-decoration:none;font-weight:600}
.ep-pasos small{display:block;font-size:.75rem;text-transform:uppercase;letter-spacing:.08em;color:var(--tinta-2);font-weight:400}
.ep-pasos a[rel=next]{text-align:right}
/* índice A-Z */
.ep-alfa{background:var(--lila);border-radius:var(--radio);padding:1rem 1.3rem;margin-bottom:1rem}
.ep-alfa p{font-weight:700;margin:0 0 .4rem;font-size:.85rem;text-transform:uppercase;letter-spacing:.07em}
.ep-alfa ul{list-style:none;margin:0;padding:0;display:flex;flex-wrap:wrap;gap:.3rem 1.1rem;font-size:.95rem}
.ep-fam h2{color:var(--f);border-bottom:2px solid var(--f);padding-bottom:.4rem}
.ep-fam>p{color:var(--tinta-2);max-width:48rem}
.ep-fam ul{list-style:none;margin:0;padding:0;display:grid;grid-template-columns:repeat(auto-fill,minmax(21rem,1fr));gap:.9rem}
.ep-fam a{display:flex;gap:1rem;align-items:flex-start;background:#fff;border:1px solid var(--linea);border-radius:var(--radio);padding:1rem;text-decoration:none;color:var(--tinta-2);font-size:.92rem;line-height:1.5;height:100%}
.ep-fam a:hover{border-color:var(--f)}
.ep-fam b{flex:none;display:grid;place-items:center;width:2.8rem;height:2.8rem;border-radius:50%;background:var(--f);color:#fff;font:700 1rem "EP Titular",serif}
.ep-fam strong{display:block;color:var(--tinta);font-size:1.05rem;margin-bottom:.2rem}
/* comprar */
.ep-compra-fam h2{color:var(--f)}
.ep-compra-fam ul{list-style:none;margin:0;padding:0}
.ep-compra-fam li{border-left:3px solid var(--f);padding:.2rem 0 .2rem 1rem;margin-bottom:1.2rem}
.ep-compra-fam h3{margin-bottom:.3rem}
.ep-compra-fam h3 a{color:var(--tinta);text-decoration:none}
.ep-compra-fam p{margin:0;font-size:.97rem}
/* preguntas */
.ep-preguntas{max-width:50rem}
.ep-pregunta{border-bottom:1px solid var(--linea)}
.ep-pregunta summary{cursor:pointer;list-style:none;font:600 1.2rem/1.35 "EP Titular",serif;padding:1.1rem 2.5rem 1.1rem 0;position:relative}
.ep-pregunta summary::-webkit-details-marker{display:none}
.ep-pregunta summary::after{content:"+";position:absolute;right:.3rem;top:.8rem;font-size:1.6rem;color:var(--azafran)}
.ep-pregunta[open] summary::after{content:"–"}
.ep-pregunta p{padding-bottom:1rem;color:var(--tinta-2)}
.ep-404{text-align:center;padding-top:4rem}
.ep-404-n{font:800 7rem/1 "EP Titular",serif;color:var(--azafran);margin:0}
.ep-404 .ep-entrada{margin-inline:auto;max-width:36rem}
/* pie */
.ep-pie{background:var(--tinta);color:#cdb9d4;font-size:.9rem}
.ep-pie-in{max-width:52rem;margin:0 auto;padding:2.6rem 1.5rem;text-align:center}
.ep-pie-marca{font:600 1.6rem "EP Titular",serif;color:#fff}
.ep-pie-marca em{color:var(--azafran);font-style:normal}
.ep-pie-nav a{color:#f6e7c8;margin:0 .45rem;white-space:nowrap}
@media (max-width:900px){
.ep-portada,.ep-dos{grid-template-columns:1fr}
.ep-rueda{max-width:19rem;order:-1}
.ep-rejilla{grid-template-columns:1fr;gap:1.5rem}
.ep-lateral{position:static;order:-1}
.ep-barra{justify-content:center}
}
@media (max-width:520px){body{font-size:1rem}.ep-nav a{padding:.4rem .6rem;font-size:.9rem}.ep-hoja{padding-inline:1.1rem}}
@media (prefers-reduced-motion:reduce){html{scroll-behavior:auto}}